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Anush Chiappino-Pepe

Bioengineer/Synthetic biologist, Computational Biologist, Therapeutic seeker

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I work at the interface of synthetic biology and computational biology,

decoding and expanding genome functions that introduce new chemistries in cells.

 

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I am a Specialist (previously Swiss National Science Foundation) Postdoctoral Fellow in the laboratory of George M. Church (Genetics department) at Harvard Medical School (HMS) and the Wyss Institute for Biologically Inspired Engineering.

I am collaborating with the laboratories of Gregory Stephanopoulos (Chemical Engineering department) and Regina Barzilay (Computer Science department) at the Massachusetts Institute of Technology (MIT).

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I identify as a woman (she/her/hers), mother, Hispanic/Latina, and life-long immigrant.

I am an advocate for a friendly, diverse, and safe environment in academia, specially for mothers, women, and underrepresented minorities.

News & Events

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Latest Publications

Preventing escape and malfunction of recoded cells due to tRNA base changes

 We discovered that cells with an engineered genetic code modify or mutate its tRNAs to acquire external, fitness improving genes with a theoretically unreadable genetic code!

This finding allowed us to design a technology involving genetic code sensitive kill switches that prevents escape and malfunction of recoded cells due to tRNA base changes, while allowing incorporation of up to three distinct non-standard amino acids.
We reduced by 8 orders of magnitude the acquisition and spread of antibiotic resistance genes!

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