22. Juni
Our work on a 57-codon E. coli genome is out!
Excited to see our work on constructing and optimizing a genetic-code-engineered Escherichia coli genome published today in Nature Communications. This is a step toward building safer cellular technologies. Constructing a 57-codon Escherichia coli genome (now in six strains) turned out to be much more challenging than simply redesigning DNA sequences and assembling them. Throughout the project, we found that genome recoding affected gene expression at multiple levels. We iden
